Eisai Inc. was established in 1995 and began marketing its first product in the United States in 1997. Since then we have rapidly grown to become a fully integrated pharmaceutical business. Eisai’s areas of commercial focus include neurology, gastrointestinal disorders and oncology/critical care. The company serves as the U.S. pharmaceutical operation of Eisai Co., Ltd., a research-based human health care (hhc) company that discovers, develops and markets products throughout the world.

Eisai has a global product creation organization that includes U.S.-based R&D facilities in Massachusetts, New Jersey, North Carolina and Pennsylvania as well as manufacturing facilities in Maryland and North Carolina. The company’s areas of R&D focus include neuroscience; oncology; vascular, inflammatory and immunological reaction; and antibody-based programs.

Eisai recognizes that we are the Company’s greatest asset. To this, Eisai is committed to providing us an enabling and empowering work environment that allows us to grow and thrive. In our diverse organization, we adhere to a strict commitment to our values of Integrity, Respect, Professionalism, Quality and Teamwork. We therefore invite you to explore this job opportunity or any others that may match your qualifications and interests.

Eisai Inc. has recently launched a new, autonomous and dedicated R&D innovation unit of over 80 people focused on applying several integrated sciences to deliver novel and targeted medicines from human genetics and related sources to patients.
This unit is premised upon three strategic pillars (human biology, chemistry innovation and entrepreneurial collaboration) and organized around four scientific engines (Human Biology and Data Sciences Engine; Integrated Biology Engine; Integrated Chemistry Engine; Imaging Center of Excellence). The predominant research focus of this new unit is precision medicine therapeutics for the subset of dementia and oncology patients with immune-driven pathology (ie, immunodementia and immunooncology), with a sharp strategic focus on employing entrepreneurial collaborative and business models to accelerate delivery of innovative medicines that address unmet patient needs.

The successful candidate for Scientist, Neuroinflammation in the ImmunoNeuroscience Group will drive immunodementia drug discovery activities by developing novel disease relevant cellular assays focused on microglia and their interactions with other CNS cells using state of art cell biology techniques, screening for identification of drug candidates, and performing in vitro/ex vivo pharmacology studies. In addition the candidate would be expected to contribute to our understanding of cellular mechanisms of Alzheimer’s susceptibility genes identified from human genetic studies, working with the Target Validation Group. The ideal candidate will be a scientific leader, and scientific excellence and a drive to deliver high impact therapies are requirements for the job. A background in studying microglial/myeloid cell function and neurodegeneration is highly desired. Other responsibilities include but are not limited to:

•Design and execute essential in vitro/ex vivo experiments to set up functional assays and evaluate compounds

•Identify disease relevant mechanisms/measures on therapeutic targets identified from human genetic studies

•Present concepts and results to the project team

•Identify and solve significant problems related to the project

•Communicate and interact effectively with team members, external collaborators, and management, using clear written and oral presentation skills

Job Qualifications

•PhD/post-doc in life sciences with minimal of two years experiences working on neuroinflammation and neurodegeneration related projects

•Experience in characterization of myeloid cell activation status and phenotypes, subcellular fractionation and function, Phagosome/localization analysis

•Knowledge and practical use of confocal, multi-photon microscopy and quantification

•Strong assay development skills for drug evaluation and proof of mechanism studies (assay design and execution)

•Expertise with culturing primary microglia and neuron cells and studying the effect of microglia on neuronal functions

•The ability to perform a wide range of in vitro cell culture techniques, e.g. primary cell culture, tissue dissection, virus infection, flow cytometry, multiplex ELISA, immunocytochemistry and Western Blot etc.

•Integrity, flexibility, passion, leadership and clear communication skill are essential, and the ability to work proactively in a team-based global organization

•Travel Requirement: Approximately 5% travel

Here at Eisai, we are rewarded with highly competitive salaries, incentive awards, a comprehensive benefits package (Medical, Dental, Prescription and Vision Plans) 401k, Flexible Spending Accounts, Life and Disability Insurance, and other great programs.

Eisai is committed to a policy of equal employment opportunity for all employees and applicants. The Company also strives for a work environment free from discrimination and harassment. It is Eisai’s policy to comply with all applicable federal, state and local laws and regulations regarding nondiscrimination in employment and not to discriminate against any employee or applicant for employment on the basis of any protected status, including, but not limited to, race, color, national origin, religion, sex, age, disability, pregnancy, ancestry, creed, alienage or citizenship status, sexual orientation, gender identity and expression, marital status, military/veteran status, genetic information, or any other protected characteristic as established by law.

Eisai is an Equal Opportunity Employer – Minority / Female / Disability / Vet from tblHiringOrgDefaults